Dodatkowe informacje

Oficjalne informacje na temat szczepionek koniugowanych (Hib, PCV)

 

Lista badań i publikacji pokazujących zmiany w „ekosystemie” bakteryjnym i wynikające z tego konsekwencje

  • Effect of introduction of the pneumococcal conjugate vaccine on drug-resistant Streptococcus pneumoniae, N Engl J Med 2006: „CONCLUSIONS: The rate of antibiotic-resistant invasive pneumococcal infections decreased in young children and older persons after the introduction of the conjugate vaccine. There was an increase in infections caused by serotypes not included in the vaccine. (…) An increase was seen in disease caused by serotype 19A, a serotype not included in the vaccine (from 2.0 to 8.3 per 100,000 among children under two years of age
  • Carriage of Streptococcus pneumoniae 3 Years after Start of Vaccination Program, the Netherlands, CDC EID Journal Home 2011: „Non-PCV7 serotype prevalences were 29% and 39% among 11-month-old children, 30% and 45% among 24-month-old children, and 8% and 15% among parents, respectively; serotypes 11A and 19A were most frequently isolated. PCV7 serotypes were largely replaced by non-PCV7 serotypes. Disappearance of PCV7 serotypes in parents suggests strong transmission reduction through vaccination.”
  • TRENDS IN HOSPITALIZATION FOR EMPYEMA IN ALASKA NATIVE CHILDREN YOUNGER THAN 10 YEARS OF AGE, Pediatr Infect Dis J. 2010: „We analyzed hospitalizations for empyema among Alaska Native (AN) children and the general population of US children <10 years during the years 1998 to 2007. We also analyzed invasive pneumococcal disease in AN children. Between 1998 and 2000, the average annual hospitalization rate for empyema was higher for AN children (51.8 per 100,000/yr) than that for US children (24.2 [95% confidence interval: 20.4, 27.9] per 100,000/yr), and had increased in 2004-2007 in both populations (59.6 and 36.0 [95% confidence interval: 30.1, 41.8], respectively). Pneumococcal empyema increased in AN children despite a decrease in invasive pneumococcal disease pneumonia.”
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